Curated Data based on Instance of Characterization
As Received
Nanomaterial State:
Not Reported
  • Physico-Chemical Characteristics
  • biological interactions
  • Environmental interactions
Particle Size

Primary Particle Size:
500 nm +/- 70 nm
Overall nanomaterial
Manufacturer Name:
CORE (hover over circle for proportion of material)
arrow Proportion of Nanomaterial:    Not reported
Component 1
Molecular Identity:
Amorphous Silica

Material Type:
Metal Oxide

In Vitro Study 1; Gene Expression; Microarray Scanner

Test Subject
Test Subject 1:
Cell Culture Type: cultured cell line
Name: RAW 264.7 - murine leukaemic monocyte macrophage cell line
General Study Details
Test Location: laboratory
Controls Used/Reported: Positive, Negative
Standard Protocol Used: MicroArray Scanner
Assay Used:
Manufacturer: Invitrogen
Assay Name: RNeasy
Exposure Summary
Method of Exposure: inoculation
Acute or Chronic Exposure: Acute exposure
Intended Dose: 5, 20, 50, 250, 500, 1000 µg/mL
Duration of Exposure / Incubation Time: 2 hours
Mechanistic Analysis:
Gene Expression: Reported Quantitatively
As Processed A
Nanomaterial State:
liquid suspension
Processing Type:
  • Physico-Chemical Characteristics
  • biological interactions
  • Environmental interactions
Particle Size

Mean Hydrodynamic Diameter:
Intensity Weighted:
420 nm +/- 15 nm
Dynamic Light Scattering

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MIAN-specific data are curated from data sources and presented on the nanomaterial details page, below. When available, the original publication link is provided so that you can verify the source data and access data that is outside of the NR MIAN. The NR Descriptor is a high level classification of the nanomaterial based on primary composition and shape.
Instance of Characterization (IOC) is a classification and description of the nanomaterial’s surrounding environment and time at which it was characterized. Each IOC at which the nanomaterial was characterized or studied is listed in the left side page navigation bar. You can click on an IOC in the navigation bar to see the curated data associated with that particular IOC.
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Data for physico-chemical characteristics (PCC) and interaction studies are curated when available. Physico-chemical characteristics are curated based upon the Registry’s Minimal Information about Nanomaterials (MIAN). Data from studies are contained on the Biological and Environmental Interaction tab and are summarized using four categories: General Study Details, Test Subject(s), Exposure Summary(s), and Endpoint(s).
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