Curated Data based on Instance of Characterization
As Synthesized
 
  • Physico-Chemical Characteristics
  • biological interactions
  • Environmental interactions
Composition
graph
CORE (hover over circle for proportion of material)
arrow Proportion of Nanomaterial:    Not reported
Component 1
Material Type:
metal oxide
Molecular Identity:
iron oxide
SHELL 1 (hover over circle for proportion of material)
arrow Proportion of Nanomaterial:    Not reported
Component 1
Material Type:
polymer
Molecular Identity:
polyvinyl alcohol

SHELL 2 (hover over circle for proportion of material)
arrow Proportion of Nanomaterial:    Not reported
Component 1
Material Type:
Biological Type:

protein
Molecular Identity:
protamine

COATING (hover over circle for proportion of material)
arrow Proportion of Nanomaterial:    Not reported
Component 1
Molecular Identity:
5-carboxytetramethylrhodamine

Solubility

Hydrophilic or Lipophilic?:
"W" - Hydrophilic (log D < 0)

In Vitro Study 1

Test Subject
Test Subject 1:
Cell Culture Type: cultured cell line
Name: HepG2 (liver hepatocytes)
Test Subject 2:
Cell Culture Type: cultured cell line
Name: monocyte/macrophage
Test Subject 3:
Cell Culture Type: cultured cell line
Name: aortic endothelial
Test Subject 4:
Cell Culture Type: cultured cell line
Name: vascular smooth muscle
General Study Details
General:
Test Location: laboratory
Assay Used:
Assay 1: Apo-ONE Homogeneous caspase 3 apoptosis
Assay 2: Live/Dead Cell Viability Assay Kit C12 Resazurin
Assay 3: CellTiter-Glo® Luminescent Cell Viability Assay
Assay 4: JC-1 Mitochondrial Membrane Potential Assay Kit
Exposure Summary
General:
Method of Exposure: inoculation
Acute or Chronic Exposure: Acute exposure
Intended Dose: 0.01, 0.03, 0.1, 0.3 mg/mL
Duration of Exposure / Incubation Time: 4 hours
Endpoint
Toxicity:
Cytotoxicity: Detected Quantitatively
As Processed A
 
  • Physico-Chemical Characteristics
  • biological interactions
  • Environmental interactions
Particle Size

Mean Hydrodynamic Diameter:
Intensity Weighted:
20 - 60 nm
Dynamic Light Scattering
Surface Charge

Zeta Potential:
0.25 mV
Electrophoretic Light Scattering

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MIAN-specific data are curated from data sources and presented on the nanomaterial details page, below. When available, the original publication link is provided so that you can verify the source data and access data that is outside of the NR MIAN. The NR Descriptor is a high level classification of the nanomaterial based on primary composition and shape.
Instance of Characterization (IOC) is a classification and description of the nanomaterial’s surrounding environment and time at which it was characterized. Each IOC at which the nanomaterial was characterized or studied is listed in the left side page navigation bar. You can click on an IOC in the navigation bar to see the curated data associated with that particular IOC.
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Data for physico-chemical characteristics (PCC) and interaction studies are curated when available. Physico-chemical characteristics are curated based upon the Registry’s Minimal Information about Nanomaterials (MIAN). Data from studies are contained on the Biological and Environmental Interaction tab and are summarized using four categories: General Study Details, Test Subject(s), Exposure Summary(s), and Endpoint(s).
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