The Nanomaterial Registry's Minimal Information About Nanomaterials (MIAN)

Seen below are the first versions of the MIAN for physico-chemical characteristics (PCCs) and of the MIAN for biological interaction studies and environmental interaction studies. The Nanomaterial Registry uses the MIAN to calculate compliance level as well as determine nanomaterial record similarity.

  • Aggregation /
    Agglomeration
    State
    Shape
    Purity
    Particle Size
    Surface
    Chemistry
    Solubility
    Size
    Distribution
    Surface Area
    Composition
    Surface
    Charge
    Stability
    Surface
    Reactivity
  • Test Subject
    CELL CULTURE
    • Isolated, suspended
    • Primary Culture
    • Cultured Cell Line
    • Genetically Engineered Cell Line
    • Reaggregated
    • 3-Dimensional
    • Co-Cultured
    ANIMAL (TERRESTRIAL OR AQUATIC)
    • Primate
    • Rodent
    • Bird
    • Insect
    • Small Mammal
    • Fish
    • Invertebrate
    PLANT (TERRESTRIAL OR AQUATIC)
    • Algae
    • Fern
    • Flower
    • Fungus
    • Moss
    • Shrub
    • Tree
    DETAILS
    • Common Name
    • Species
    • Strain
    • Transgenic Model
    • Number
    • Lifestage
    • Age
    • Sex
    • Race
    • Conditions / Susceptibilities
    GENERAL STUDY
    DETAILS
    TEST LOCATION
    • Laboratory
    • Field, simulated
    • Field, acutal
    CONTROLS USED/REPORTED
    STANDARD PROTOCOL USED
    ASSAY USED
    • ManufacturerAssay Name
    Exposure
    Summary
    METHOD OF EXPOSURE
    • Absorption
    • Aerosol
    • Dermal
    • Endotracheal
    • Inhalation - Whole Body
    • Inhalation - Nose Only
    • Injection
    • Innoculation
    • Instillation
    • Oral
    • Oral Gavage
    • Oropharyngeal
    Acute or Chronic Exposure
    Intended Dose
    Actual Dose
    Frequency of Dose
    (Chronic Exposure Only)
    Duration of Exposure
    Duration between Exposure and Measurement
    ENDPOINT
    Toxicity
    Pharmacodynamics
    • Cardiovascular System
    • Digestive System
    • Endocrine System
    • Excretory System
    • Integumentary System
    • Lymphatic/Immune System
    • Muscular System
    • Nervous System
    • Reproductive System
    • Respiratory System
    • Skeletal System
    • Root System (Plants)
    • Shoot System (Plants)
    BIODISTRIBUTION
    BIOTRANSFORMATION
  • TEST MEDIA
    AIR
    WATER (FRESH, SALT, RECONSTITUTED, DISTILLED, TAP)
    • Alkinity
    • Conductivity
    • Dissolved Oxygen
    • Hardness
    • Ionic Fractionli>
    • pH
    • Salinity
    • Total Organic Carbon
    • TemperatureTotal Weight or Volume
    SOIL (NATURAL, ARTIFICIAL)
    • Name
    • Heavy Metals Reported?
    • Total Organic Carbon
    • Moisture
    • pH
    • Void Volume
    • Total Weight of Volume
    GENERAL STUDY
    DETAILS
    TEST LOCATION
    • Field, simulated
    • Field, acutal
    • Occupational
    CONTROLS USED/REPORTED
    STANDARD PROTOCOL USED
    ASSAY USED
    • Manufacturer
    • Assay Name
    Exposure
    Summary
    CONCENTRATION IN MEDIA
    ENDPOINT
    FATE & TRANSPORT
    TRANSFORMATION

PCC MIAN

With our Advisory Board, the Nanomaterial Registry has developed a MIAN for the physico-chemical characterization of nanomaterials. The scope of this MIAN includes the most descriptive characteristics of a nanomaterial—the characteristics that govern a nanomaterial's interaction with biological and environmental systems. Nanomaterial PCCs are highly affected by their surroundings, consequently affecting a nanomaterial's behavior in any given system.

The PCC MIAN, while capturing minimal characteristics, is deep in its capacity to capture characteristic data as well as the protocols, parameters, and metadata associated with each measurement. We do this with the understanding that instrument settings can greatly impact the data received during an analysis. The Registry team believes that this depth will encourage the adoption of greater reporting in literature and also will promote standards creation about data collection and communication. Within the PCC MIAN, the most relevant measurands, units, techniques, protocols, and instrument parameters have been identified in order to form a controlled vocabulary for use during curation.

Within the PCC MIAN are also best practice questions, which are used for evaluating the quality of the characterization. The best practice questions that are applied to each measurement value are the following:

1) Are raw data provided by the data source?
2) Were proper controls used and reported?
3) Was the instrument within calibration?
4) How many replicates were performed?
5) Was the measurement protocol reported?
6) Was there a citation to the protocol?
7) Were there modifications made to the cited protocol?

Biological and Environmental MIAN

The Nanomaterial Registry has also created a MIAN for studies performed on the biological and environmental implications of nanomaterials. The minimal information for studies ensures that the data from studies are curated in a way that summarizes the vital information in the study and helps the user better interpret how the study was performed and what its conclusions were.


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